Participants with suspected leukemia will undergo a bone marrow aspirate or biopsy procedure to remove about 3 to 4 teaspoons of bone marrow, which will be analyzed to establish the diagnosis of ALL, as well as sent to the Childrens Oncology Group tissue bank for research. Blood and bone marrow samples will be used to classify participants with the disease into low, standard, high and very high risk categories. Induction treatment will be initiated based upon risk assessment. Days 8 and 29 of induction will involve testing of peripheral blood and bone marrow, respectively, to determine minimal residual disease.
Newly diagnosed or suspected acute leukemia
Appropriate level of disease
Must be 18 years or younger at time of diagnosis
Adequate amounts of bone marrow and/or peripheral blood samples