The lifesaving clinical trial
Even though Carol’s surgery showed “no residual cancer left behind,” Carol was given postsurgical chemotherapy because of the aggressiveness of the disease. Experiencing taxing side effects, she was only able to tolerate four additional cycles of this chemotherapy. That was when Dr. Fratamico let her know about the ELI-002 pancreatic cancer vaccine clinical trial.
The Cancer Institute is known for its intensive research and innovative treatments. This work is championed by expert clinicians, who create personalized treatment plans to address a patient’s individual disease state. The Cancer Institute is also home to the Peter and Odete Kelly Center for Personalized Cancer Immunotherapy, which enables access to higher-profile clinical trials.
“I recommended the trial for Carol because she is a very motivated patient,” Dr. Fratamico says. “The purpose of the vaccine is to increase the probability of cure as much as possible and engage the immune system to eliminate any disease that may not be evident on conventional imaging and prior to causing symptoms or abnormalities otherwise.”
Carol was excited that Lehigh Valley Topper Cancer Institute, part of Jefferson Health, was participating in a clinical trial evaluating an immunotherapeutic pancreatic cancer vaccine. She researched and studied the trial.
“Average life expectancy is three years if I do nothing, so, why wouldn’t I try it,” Carols says. “I decided I wanted to do this in the hopes that (even if it didn’t work for me,) it would provide desperately needed research in advancement of pancreatic cancer care and I would help make that possible for future generations.” Carol put her hopes into the Cancer Institute and its expert team of clinicians.
In October 2024, Carol underwent a research procedure to collect T cells for the study and then received a total of 10 doses of study treatment (40 vaccines). The last dose was given in March 2025, and she has been closely followed with serial labs and imaging, with no evidence of disease to date.
“Carol is doing wonderfully,” Dr. Fratamico says. “Along with others in the ELI-002 investigational trial, she exemplifies the likely benefits derived from the therapy and what may be possible for similar patients in the future.”